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Noninvasive retinal markers in diabetic retinopathy: advancing from bench towards bedside
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نویسنده
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blindbæk sø.l. ,torp t.l. ,lundberg k. ,soelberg k. ,vergmann a.s. ,poulsen c.dø. ,frydkjaer-olsen u. ,broe r. ,rasmussen m.l. ,wied j. ,lind m. ,vestergaard a.hø. ,peto t. ,grauslund j.
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منبع
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journal of diabetes research - 2017 - دوره : 2017 - شماره : 0
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چکیده
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The retinal vascular system is the only part of the human body available for direct,in vivo inspection. noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. likewise,the retinal metabolism can be evaluated by retinal oximetry,and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. so far,most studies have been cross-sectional,but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. likewise,retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. the department of ophthalmology at odense university hospital,denmark,has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. in the present paper,we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes. © 2017 søren leer blindbæk et al.
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آدرس
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department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of neurology,kolding hospital,hospital lillebaelt,kolding,denmark,department of regional health research,university of southern denmark,odense,denmark,institute of molecular medicine,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense,denmark,odense patient data explorative network (open),odense university hospital,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark, department of clinical research,university of southern denmark,odense,denmark,nihr biomedical research centre,moorfields eye hospital nhs foundation trust,ucl institute of ophthalmology,london,united kingdom,queen's university belfast,belfast, United Kingdom, department of ophthalmology,odense university hospital,odense,denmark,department of clinical research,university of southern denmark,odense, Denmark
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Authors
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