Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance,the underlying mechanism is not completely understood. inflammatory regulation has been focused on innate immunity especially macrophage for a long time,while increasing evidence suggests t cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. there was growing evidence supporting the critical implication of t cells in the pathogenesis of type 2 diabetes. we will discuss the available effect of t cells subsets in adaptive immune system associated with the procession of t2dm,which may unveil several potential strategies that could provide successful therapies in the future. © 2017 chang xia et al.