Arterial Stiffness is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: the REBOUND Study

Aim. the aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (gfr) in patients with type 2 diabetes mellitus. methods. this multicenter cohort study analyzed 2613 patients with type 2 diabetes. brachial-ankle pulse wave velocity (bapwv) was used as a noninvasive marker of arterial stiffness. additionally,the patients were categorized into four groups according to their albumin-to-creatinine ratio (acr,normoalbuminuria versus albuminuria) and estimated gfr (egfr,<60 ml/min/1.73 m2 versus ≥60 ml/min/1.73 m2). results. a univariate analysis revealed that maximal bapwv was significantly associated with both the acr (r=0.297,p<0.001) and egfr (r=-0.220,p<0.001). a multivariate analysis adjusted for significant clinical variables and egfr showed that bapwv remained significantly correlated with the acr (r=0.150,p<0.001). also,bapwv was correlated positively with the acr in patients with an egfr ≥ 60 ml/min/1.73 m2 (r=0.146,p<0.001). however,bapwv was not correlated with egfr after adjustment for significant clinical variables. conclusions. the present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in gfr in patients with type 2 diabetes mellitus. © 2017 jong ho kim et al.