Synthesis,evaluation and characterization of some 1,3,4-triazole-2-one derivatives as antimicrobial agents

A series of novel compounds like 3[(phenyl substituted)-5- methyl-1(benzosulphonylamine)]-1,3,4-triazole-2-ones ii(a-f) were synthesized by treating 4-amino-1-phenyl-3-methyl-5-oxo-1,2,4-triazoles with benzene sulphonyl chloride using pyridine as solvent. similarly by using 4-amino-1-aryl-3-methyl- 5-oxo-1,2,4-triazoles and acetic anhydride as starting material 3[(phenyl substituted)-5-methyl-1(acetylamino)]- 1,3,4-triazole-2-ones iii(a-f) were synthesized and also 3[(phenyl substituted)-5-methyl-1(chloroacetyl)]-1,3,4- triazole-2-ones i(a-f) were synthesized by treating 4-amino-1-aryl-3-methyl-5- oxo-1,2,4-triazoles with chloroacetyl chloride in presence of a non-polar solvent like benzene. elemental analysis,gcms,ir,and 1h nmr confirmed the structures of the newly synthesised compounds. the newly synthesized compounds are also screened for their antibacterial,antifungal and anti-inflammatory activities.