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Synthesis and anticancer activity of some new derivatives of coumarin and quinolinyl mercaptotriazoles
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نویسنده
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hosny m.a. ,radwan h.a. ,el-sawi e.a.
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منبع
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journal of chemistry - 2012 - دوره : 9 - شماره : 4 - صفحه:1737 -1745
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چکیده
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Pechmann condensation of ethylacetoacetate with derivatives of phenol by heating in absence of solvent and with montmorillonite clays k-10 afforded coumarin derivatives (1a-e) in good yields which on reaction with thiosemicarbazide in anhydrous pyridine yielded coumarin-quinolinyl mercaptotriazole (2a-e). the latter compounds were evaluated for their antimicrobial and anticancer activities. the newly synthesized compounds were characterized by ir,1hnmr and mass spectra. © 2012 hindawi publishing corporation.
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کلیدواژه
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Coumarin; Mercaptotriazole; Thiol
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آدرس
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department of chemistry,faculty of women for arts science and education,ain shams university, Egypt, department of chemistry,faculty of women for arts science and education,ain shams university, Egypt, department of chemistry,faculty of women for arts science and education,ain shams university, Egypt
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Authors
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