Synthesis and anti-inflammatory activity of a novel series of diphenyl-1,2,4-triazoles and related derivatives

In the present investigation we have synthesized a series of new 1-[3-(4-substitutedphenyl)-5-phenyl-4h-1,2,4-triazol-4-yl]urea and 1-[3-(4-substitutedphenyl)-5-phenyl-4h-1,2,4-triazol-4-yl]thiourea derivatives (4ia - 4iid). the newly synthesised derivatives were characterized by using the data of ir,1 h nmr and mass spectral analysis. thus synthesised and characterized targetted compounds were further screened for their anti-inflammatory activity by using carrageenan - induced paw edema rat model. among all the newly synthesized derivatives,compounds 4ia-4ic and compounds 4iia-4iid were reduced the inflammation very significantly (p <0.0001),thus these compounds showed promising anti-inflammatory activity and only one compound (4id) showed moderate anti-inflammatory activity (p <0.05). © 2012 hindawi publishing corporation.