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Synthesis and anti-inflammatory activity of a novel series of diphenyl-1,2,4-triazoles and related derivatives
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نویسنده
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cherala s. ,lingabathula h. ,ganta r. ,ampati s. ,manda s.
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منبع
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journal of chemistry - 2012 - دوره : 9 - شماره : 4 - صفحه:2510 -2515
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چکیده
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In the present investigation we have synthesized a series of new 1-[3-(4-substitutedphenyl)-5-phenyl-4h-1,2,4-triazol-4-yl]urea and 1-[3-(4-substitutedphenyl)-5-phenyl-4h-1,2,4-triazol-4-yl]thiourea derivatives (4ia - 4iid). the newly synthesised derivatives were characterized by using the data of ir,1 h nmr and mass spectral analysis. thus synthesised and characterized targetted compounds were further screened for their anti-inflammatory activity by using carrageenan - induced paw edema rat model. among all the newly synthesized derivatives,compounds 4ia-4ic and compounds 4iia-4iid were reduced the inflammation very significantly (p <0.0001),thus these compounds showed promising anti-inflammatory activity and only one compound (4id) showed moderate anti-inflammatory activity (p <0.05). © 2012 hindawi publishing corporation.
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کلیدواژه
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4-triazoles; 1H NMR; IR; Mass Spectroscopy and anti-inflammatory activity
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آدرس
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medicinal chemistry research laboratory,university college of pharmaceutical sciences,kakatiya universtiy,warangal, India, kakatiya institute of pharmaceutical sciences,pembarthy,warangal, India, kakatiya institute of pharmaceutical sciences,pembarthy,warangal, India, kakatiya institute of pharmaceutical sciences,pembarthy,warangal, India, medicinal chemistry research laboratory,university college of pharmaceutical sciences,kakatiya universtiy,warangal, India
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Authors
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