Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2 H)-yl)acetamide based thiazolidinone derivatives as potent antibacterial and antifungal agents

Twelve compounds belonging to series 2-(3-methyl-2-oxoquinoxalin-1(2h)-yl)- n-[4-oxo-2-(substituted)phenyl-1,3-thiazolidin-3-yl]acetamide (5a-l) were synthesized. these compounds were evaluated for their in-vitro antibacterial against e. coli,s. aureus,k. pneumoniae,p. aeruginosa & antifungal activity against c. albicans,a. niger & a. flavus by cup-plate method. structures of all the newly synthesized compounds were confirmed by elemental analysis,1h-nmr & ft-ir spectral data interpretation. compounds 5d & 5h having p-nitrophenyl & p-trifluoromethylphenyl group respectively on 2-position of thiazolidinone ring attached to n-atom of acetamido group on 1-position of 3-methyl-1h-quinoxaline-2-one,were found to be active against all the bacterial & fungal strains under investigation,while compound 5l having p-chlorophenyl on 2-position of thiazolidinone nucleus was reported as least active compound against all bacterial & fungal strain under investigation. © 2012 hindawi publishing corporation.