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Syntheses,characterization,and antimicrobial screening of N-(benzothiazol-2-yl)benzenesulphonamide and its Cu(I),Ni(II),Mn(II),Co(II) and Zn(II) complexes
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نویسنده
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obasi n.l. ,chukwuma o. benedict o. ,ukoha p.o. ,anaga a.o.
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منبع
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journal of chemistry - 2012 - دوره : 9 - شماره : 4 - صفحه:2354 -2370
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چکیده
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N-(benzothiazol-2-yl)benzenesulphonamide (bs2abt) was synthesized by the condensation (by refluxing) of 2-aminobenzothiazole and benzenesulphonylchloride in acetone at 140°c. the resulting crude precipitates were recrystallized from dimethylformamide (dmf). five metal complexes of copper(i),nickel(ii),manganese(ii),cobalt(ii) and zinc(ii) of the ligands were synthesized. the compounds were characterized using magnetic susceptibility measurements,uv/vis spectrophotometry,infra red,proton and 13c nmr spectroscopies. the antimicrobial tests of the ligands and its metal complexes were carried out on both multi-resistant bacterial strains isolated under clinical conditions and cultured species using agar-well diffusion method. the multi-resistant bacterial strains used were escherichia coli,proteus species,pseudomonas aeroginosa and staphylococcus aureus which were isolated from dogs. the culture species were pseudomonas aeruginosa (atcc 27853),escherichia coli (atcc 25922) staphyl © 2012 hindawi publishing corporation.
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کلیدواژه
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Antimicrobial; Metal complexes; N-(benzothiazol-2-yl)benzenesulphonamide
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آدرس
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department of pure and industrial chemistry,university of nigeria,nsukka, Nigeria, department of pure and industrial chemistry,university of nigeria,nsukka, Nigeria, department of pure and industrial chemistry,university of nigeria,nsukka, Nigeria, department of physiology and pharmacology,university of nigeria, Nigeria
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Authors
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