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The determination of partition coefficient of 6-mercaptopurine derivatives by thin layer chromatography
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نویسنده
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czyrski a. ,kupczyk b.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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Mercaptopurine and its derivatives are used in the treatment of leukemia. to estimate their lipophilicity,a simple and novel thin layer chromatography method was developed. the mobile phase was the mixture of acetonitrile and water. the acetonitrile content varied by 5 from 50 to 80. the linear relationship between log p and r m 0 for substances with known lipophilicity was found. the lipophilicity of purine derivatives was worked out from the calibration curve. the most lipohilic compound was methylazathioprine (0.64). © 2013 andrzej czyrski and bartomiej kupczyk.
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آدرس
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department of physical pharmacy and pharmacokinetics,pozna university of medical sciences,6 świecickiego street, Poland, department of physical pharmacy and pharmacokinetics,pozna university of medical sciences,6 świecickiego street, Poland
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Authors
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