Synthesis and antimicrobial activity of some new thiazolidin-4-one derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine

A number of derivatives of 2-(substituted phenyl)-3-(4-(6-methylbenzo[d] thiazol-2-yl)phenyl) thiazolidin-4-one (3a-j) have been synthesized from the reaction of 4-(6-methylbenzo[d]thiazol-2-yl)benzenamine(1),with different substituted benzaldehydes (2a-j),followed by cyclocondensation reaction of the prepared imines with 2-meraptoacetic acid in high yields. furthermore,the structures of the newly synthesized compounds were confirmed by ft-ir,13c-nmr,13c-dept,and 1h-nmr spectral data. the imines and thiazolidin-4-one derivatives were evaluated for their antibacterial activity against escherichia coli as gram negative and staphylococcus aureus as gram positive,the results have shown significant activity against both types of bacteria. © 2013 awaz jamil hussein and hashim jalal azeez.