Synthesis and biological evaluation of novel 5,7-dichloro-1,3-benzoxazole derivatives

A new class of 5,7-dichloro-1,3-benzoxazole derivatives 4-11 were synthesized by fusing 5,7-dichloro-2-hydrazino-1,3-benzoxazole 3 nucleus with aliphatic acids,active methylene compounds,and with selected esters to form heterocyclic ring systems like 1,2,4-triazoles,pyrazoles,and triazine moieties. the compound 3 on diazotization reaction affords the tetrazole compound. the synthesized compounds were characterized by 1h nmr,ir,mass,and 13c nmr spectral data and screened for cytotoxic,antimicrobial,antioxidant,and antilipase activities. the compounds 4,5,and 8 have shown significant antimicrobial activities,whereas compounds 6 and 8 have been emerged as leading cytotoxic agents. the compounds 9,10,and 11 were found to be strong enzyme inhibitors. © 2013 n. d. jayanna et al.