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Development and validation of HLPC method for the estimation of lamotrigine in bulk and pharmaceutical formulations
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نویسنده
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reddy t.v.b. ,ramu g. ,biksham babu a. ,rambabu c.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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A simple,precise,accurate,and rapid hplc method was developed to estimate the amount of lamotrigine in bulk and its pharmaceutical formulations. waters alliance hplc system equipped with autosampler,ultraviolet detector,and symmetry c8 (4.6mm id 150mm,3.5m,make: xterra) column were used for the quantification of the drug. separation was carried out at a flow rate of 0.7ml/min. of mobile phase (acetonitrile and potassium dihydrogen phosphate buffer of p h = 7.0 in the ratio 60:40v/v),and the detection was carried out at a wavelength of 215nm. the retention time of lamotrigine was found to be 2.797min. the linearity was obeyed in the range of concentration 525g/ml. the developed method was found to be repeatable and reproducible; hence,it can be used as an alternative method in assay of the lamotrigine in any pharmaceutical industries.
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آدرس
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department of chemistry,acharya nagarjuna university,dr. m.r. apparow campus,andhra pradesh, India, department of chemistry,acharya nagarjuna university,dr. m.r. apparow campus,andhra pradesh, India, department of chemistry,acharya nagarjuna university,dr. m.r. apparow campus,andhra pradesh, India, department of chemistry,acharya nagarjuna university,dr. m.r. apparow campus,andhra pradesh, India
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Authors
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