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Synthesis of substituted thioureas and their sulfur heterocyclic systems of p -amino salicylic acid as antimycobacterial agents
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نویسنده
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makki m.s.i.t. ,abdel-rahman r.m. ,faidallah h.m. ,khan k.a.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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A series of new n,n ′-substituted thioureas (2,6,and 8) and their sulfur heterocycles as thiobarbituric acids (3,4,and 7),2-thioxothiazoliodin-4-one (10),thiazolidin-4-one (11),1,2,4-triazol-5-thione (14),and 1,3,4-thiadiazole (15) of p-amino salicylic acid (pas) have been synthesized from treatment with dithiocarbazinate (1,5 and 12) followed by heterocyclization with dimethyl malonate,chloroacetic acid,and/or trifluoroacetic anhydride. the structures of the newly synthesized compounds were substantiated with ir,h 1,and c 13 nmr spectral data and elementary microanalyses. the in vitro antitubercular activity of synthesized compounds against m. tuberculosis strain h37rv showed moderate-to-good activity. © 2013 mohammed saleh i. t. makki et al.
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آدرس
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department of chemistry,faculty of science,king abdulaziz university,p.o. box 80203, Saudi Arabia, department of chemistry,faculty of science,king abdulaziz university,p.o. box 80203, Saudi Arabia, department of chemistry,faculty of science,king abdulaziz university,p.o. box 80203, Saudi Arabia, department of chemistry,faculty of science,king abdulaziz university,p.o. box 80203, Saudi Arabia
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Authors
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