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Thermodynamic study of human serum albumin upon interaction with ytterbium (III)
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نویسنده
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behbehani g.r. ,barzegar l. ,savad koohi m.k.k. ,mohebbian m. ,abedi b.s. ,saboury a.a. ,divsalar a.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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Complexation reaction between yb3+ and human serum albumin is examined using isothermal titration calorimetry (itc). the extension solvation theory was used to reproduce the enthalpies of has + yb3+ interactions over the whole range of yb3+ concentrations. the binding parameters recovered from this model were attributed to the structural change of hsa. the results show that yb3+ ions bind to hsa with three equivalent affinity sites. it was found that in the high concentrations of the ytterbium ions,the hsa structure was destabilized.
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آدرس
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chemistry department,islamic azad university,takestan branch, ایران, chemistry department,islamic azad university,takestan branch, ایران, payame noor university, ایران, payame noor university, ایران, department of biology,islamic azad university,east tehran branch, ایران, university of tehran, ایران, university of tehran, ایران
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Authors
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