Quantitative estimation of sorafenib tosylate its pure form and in its tablet formulation by RP-HPLC method

A simple,accurate,specific reverse-phase,high-performance liquid chromatography method has been developed for the determination of sorafenib tosylate in its pure form and its tablets. in this method,sorafenib tosylate was eluted by isocratic mode using a phenomenex luna c18 column by a mobile phase composition of acetonitrile and water in the ratio of 82.5: 17.5,v/v. the flow rate was 1.5 ml/min. the eluted drug was monitored at 265 nm and the method was found to be linear from 5 to 80 μg/ml. the method was validated by linearity,precision,accuracy,lod,and loq. the accuracy report denotes that there is not any interference of additives used in the formulation. © 2013 r. kalaichelvi and e. jayachandran.