Synthesis of (±)-pisonivanone and other analogs as potent antituberculosis agents

A new class of alkylated chalcones and flavanones was synthesised and screened for antituberculosis,antixoidant,and cytotoxic activities. the desired compounds were synthesised using methyl substituted 2- hydroxyacetophenone as a key intermediate. the acetophenone derivative having methyl substitution was prepared in turn from methtylated phloroglucinol by formylation (by vilsmeier-haack reaction),followed by reduction with wolf-kishnner approach,and finally acetylation was involved. among 17 compounds,compound 5 and compound 4a inhibited m. tuberculosis at minimum inhibitory concentration (mic) in the range between 25 g/ml and 50 g/ml. the remaining other 15 compounds also potently inhibited m. tuberculosis at mic in range between 50 g/ml and 100 g/ml. some of these compounds also showed moderate antioxidant and cytotoxic activities. © 2013 a. vasu babu et al.