Microwave-assisted synthesis,characterization,antimicrobial and antioxidant activity of some new Isatin derivatives

A series of β-isatin aldehyde-n,n'-thiocarbohydrazone derivatives were synthesized and assayed for their in vitro antimicrobial and antioxidant activity. the new compounds were characterized based on spectral (ft-ir,nmr,ms) analyses. all the test compounds possessed a broad spectrum of activity having mic values rangeing from 12.5 to 400 μg/ml against the tested microorganisms. among the compounds 3e,3j and 3n show highest significant antimicrobial activity. the free radical scavenging effects of the test compounds against stable free radical dpph (α,α-diphenyl-β- picryl hydrazyl) and h 2o 2 were measured spectrophotometrically. compounds 3j,3n,3l,and 3e,respectively,had the most effective antioxidant activity against dpph and h 2o 2 scavenging activity. © 2013 g. kiran et al.