Thioxopyrimidine in heterocyclic synthesis I: Synthesis of some novel 6-(heteroatom-substituted)-(thio)pyrimidine derivatives

A series of novel n-cycloalkanes,morpholine,piperazines,pyrazole,pyrimidine,benzimidazolo[1,2-a]pyrimidine,1,2,3,4-tetrazolo[1,5-a]pyrimidine,azopyrazolo[1,5- a]pyrimidine,pyrimido[4',5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives incorporating a 5-cyano-4-methyl-2-phenyl-(thio) pyrimidine moiety were obtained by the intramolecular cyclization of 6-methylthio-pyrimidine,6-(benzoylmethyl)thio- pyrimidine and 2-[(5-cyano-4-methyl-2-phenylpyrimidin-6-yl)thio]-3-dimethyl- amino-1-phenyl-prop-2-en-1-one with appropriate amines and enaminone compounds,respectively. the structure of all new synthesized compounds was established from their spectral data,elemental analysis and the x-ray crystal analysis. © 2013 yuh-wen ho and maw cherng suen.