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Antiadhesive property of photoreactive azidophenyl low-molecular-weight chitosan in rabbit laminotomy model
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نویسنده
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kim j.w. ,song k.-s. ,kang h. ,jang e.-c. ,kim m.k. ,son t.i.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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Newly developed photoreactive azidophenyl chitosan (p-almc) has characteristics of a transformable gel type and its outer layer could be sealed up like a film after uv radiation. we aim to evaluate the antiadhesive properties of p-almc through comparing it with hyaluronic acid- carboxymethylcellulose membrane (ha-cmc) in a rabbit laminotomy model. laminotomies were performed at the l3-4,l4-5,and l5-6 levels in 41 rabbits and each level was randomly assigned to either receive saline (group i),ha-cmc (group ii),or p-almc (group iii). the extent of peridural fibrosis,density of fibroblasts and inflammatory cells,and dural thickness were evaluated at 6 and 12 weeks postoperatively. in the groups ii and iii,the extents of peridural fibrosis and dural thickness were significantly smaller than those in group i (p < 0.001) and no differences between groups ii and iii were found at the postoperative 6 and 12 weeks. there were no differences of cell density among groups. p-almc showed effective antiadhesive properties comparable to ha-cmc and could be one of the candidates as an anti-adhesive agent for spine surgery even further study is required to identify the effectiveness of its unique characteristics as mechanical barrier. © 2013 jong won kim et al.
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آدرس
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department of orthopaedic surgery,gang-nam himchan hospital,20-8 songpa-dong,songpa-gu, South Korea, department of orthopedic surgery,college of medicine,chung-ang university,heukseok-dong,dongjak-gu, South Korea, department of anesthesiology and pain medicine,college of medicine,chung-ang university,heukseok-dong,dongjak-gu, South Korea, department of orthopedic surgery,college of medicine,chung-ang university,heukseok-dong,dongjak-gu, South Korea, department of pathology,college of medicine,chung-ang university,heukseok-dong,dongjak-gu, South Korea, department of biotechnology and bio-environmental technology (bet),research institute,chung-ang university, South Korea
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Authors
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