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Antifungal constituents from the roots of Piper dilatatum Rich.
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نویسنده
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dos santos r.a. ,ramos c.s. ,young m.c.m. ,pinheiro t.g. ,amorim a.m. ,kato m.j. ,batista r.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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The compounds (+)-(7s,8r)-epoxy-5,6-didehydrokavain (1),flavokavain b (2),β-sitosterol (3),and stigmasterol (4) are reported here as chemical constituents of piper dilatatum rich. (piperaceae). their structures were determined on the basis of their spectroscopic data (1h and 13c nmr,ms,and ir). the antifungal activities of pyrone 1 (1 g) and chalcone 2 (100 g) were determined by means of direct bioautography against cladosporium cladosporioides and c. sphaerospermum. results indicate p. dilatatum as a candidate for the development of novel antifungal phytotherapic products as well as point out pyrone 1 as a promising hit compound in the quest for novel antifungal agents. © 2013 ruilan alves dos santos et al.
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آدرس
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departamento de estudos básicos e instrumentais,universidade estadual do sudoeste da bahia,br 415,km 03,s/n,45700-000 itapetinga, Brazil, departamento de ciências moleculares,universidade federal rural de pernambuco,rua dom manoel de medeiros,s/n,52171-030 recife, Brazil, seção de fisiologia e bioquímica de plantas,instituto de botânica,cp 3005,01061-970 são paulo, Brazil, departamento de estudos básicos e instrumentais,universidade estadual do sudoeste da bahia,br 415,km 03,s/n,45700-000 itapetinga, Brazil, departamento de ciências biológicas,universidade estadual de santa cruz,rodovia ilhéus-itabuna,km 16,45662-900 ilhéus, Brazil, instituto de química,universidade de são paulo,cp 26077,05513-970 são paulo, Brazil, instituto de química,universidade federal da bahia,rua barão de geremoabo,s/n,ondina,40170-290 salvador, Brazil
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Authors
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