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   Convenient synthesis of 1,4-dideoxy-1,4-imino-D-ribitol from D-ribose  
   
نویسنده oba m. ,kawaji s. ,kushima h. ,sano t. ,nishiyama k.
منبع journal of chemistry - 2013 - دوره : 2013 - شماره : 0
چکیده    This paper describes a convenient synthesis of 1,4-dideoxy-1,4-imino-d- ribitol (drb) from d-ribose. l-lyxonolactone,a key intermediate in this synthesis,was prepared by base-promoted hydrolysis of a 5-chlorinated d-ribonolactone derivative with inversion of configuration at the c-4 position. cyclization of the generated dimesylated l-lyxitol with benzylamine proceeded with another configurational inversion at c-4 to afford the d-ribo-configured pyrrolidine system,which upon deprotection gave drb. © 2013 makoto oba et al.
آدرس department of materials chemistry,tokai university,317 nishino,numazu, Japan, department of materials chemistry,tokai university,317 nishino,numazu, Japan, department of materials chemistry,tokai university,317 nishino,numazu, Japan, department of materials chemistry,tokai university,317 nishino,numazu, Japan, department of materials chemistry,tokai university,317 nishino,numazu, Japan
 
     
   
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