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Enantioselective synthesis of antiepileptic agent,(-)-Levetiracetam,through evans asymmetric strategy
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نویسنده
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chandra babu k. ,buchi reddy r. ,mukkanti k. ,suresh k. ,madhusudhan g. ,nigam s.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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A practical and efficient enantioselective synthesis of antiepileptic drug,(-)-levetiracetam,has been described in five steps (33.0% overall yield) and high optical purity (99.0% ee),using evans asymmetric strategy for α -alkylation of carbonyl functionality as the key step. the simplicity of the experimental procedures and high stereochemical outcome make this method synthetically attractive for preparing the target compound on multigram scales. © 2013 k. chandra babu et al.
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آدرس
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department of research and development,inogent laboratories private limited,28a,ida nacharam,hyderabad 500 076,india,centre for pharmaceutical sciences,institute of science and technology,jawaharlal nehru technological university,kukatpally, India, r and d centre,orchid chemicals and pharmaceuticals ltd.,476/14,sholinganallur, India, centre for pharmaceutical sciences,institute of science and technology,jawaharlal nehru technological university,kukatpally, India, department of research and development,inogent laboratories private limited,28a,ida nacharam, India, department of research and development,inogent laboratories private limited,28a,ida nacharam, India, department of research and development,inogent laboratories private limited,28a,ida nacharam, India
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Authors
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