Synthesis,molecular modeling,and biological activity of zinc(II) salts with 1,4-Bis(benzimidazol-2-yl)benzene

Zinc(ii) halides and perchlorate react with 1,4-bis(benzimidazol-2-yl) benzene (l) in 1: 2 molar ratio in n-butanol/2-methoxy ethanol (10 ml) at refluxing temperature to produce white/pale yellow-colored complexes of the formulae [zncl2l]h2o,[znbr2l]3h2o,and [zn(oclo3)2l]hoch2ch2ch 2ch3. zinc(ii) iodide also reacts with l in 1: 2 molar ratio in n-butanol (hoch2ch2ch2ch3) to yield white-colored complex of the formula [znl2(och 2ch2ch2ch3)2]. the complexes were characterized by elemental analysis,molar conductance measurements,thermal analysis,and ir,1h-,13c-nmr spectral studies. the complexes showed significant anthelmintic activity. the minimum energy configuration has been obtained for the zinc complexes using molecular modeling pro plus; a tool developed by chemsw,inc,usa. © 2013 g. krishnamurthy.