Preparation of New α -aminophosphonate derivatives by kabachnik-fields reaction using a recyclable catalyst

A convenient and efficient synthetic method for the preparation of some new α-aminophosphonate derivatives via a one-pot three-component system has been achieved using amberlite irc-748 as a recyclable catalyst. this method not only provides an excellent complement for the synthesis of α- aminophosphonates but also avoids the use of hazardous acids or expensive/toxic lewis acids and harsh reaction conditions. most of the synthesized compounds (4a-o) exhibited activity against bacteria/fungi strains and moderate dpph radical scavenging activity. © 2013 nellisara d. shashikumar.