Anti-inflammatory,analgesic evaluation and molecular docking studies of N-phenyl anthranilic acid-based 1,3,4-oxadiazole analogues

A novel series of n-phenyl anthranilic acid-based 1,3,4-oxadiazoles were prepared (4a-h) and subjected to anti-inflammatory,analgesic activity and molecular docking studies to target cyclooxygenase-2 enzyme. 1,3,4-oxadiazole derivatives were screened for anti-inflammatory activity in carrageenan-induced rat paw edema and analgesic activity by tail immersion method. in synthesized compounds,the free carboxylic group,which is responsible for gastric side effects,was derivatized by heterocyclic 1,3,4-oxadiazole bioactive core,which showed good interaction with cox-2 receptor with good docking score. among all the synthesized compounds,4e and 4f have emerged out as potential cox-2 inhibitors. © 2013 suman bala et al.