Cellulose-sulfuric acid as an efficient biosupported catalyst in one-pot synthesis of novel heteroaryl substituted 1,4-dihydropyridines

An efficient method for the synthesis of new heteroaryl substituted dihydropyridine derivatives via a one-pot four-component coupling reaction of heteroaldehyde,1,3-diketone,ethylacetoacetate,and amonium acetate in the presence of cellulose-sulfuric acid as a biosupported solid acid catalyst was developed. the reaction gave the new derivatives of fused 1,4-dihydropyridines in lower reaction times and excellent yields (85-95%). © 2013 manouchehr mamaghani et al.