Synthesis and antimicrobial evaluation of a new series of N -1,3-benzothiazol-2-ylbenzamides

Enterococcus faecalis is a gram-positive commensal inhabitant of the intestinal tract of humans,animals,and insects. however,it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections. fluoroquinolones have been frequently used to treat e. faecalis infections,and the emergence of fluoroquinolone-resistant e. faecalis strains has recently been reported in several countries. thus,the identifications of new antibiotics specifically directed to e. faecalis may be envisaged. in this paper,a new series of n-1,3-benzothiazol-2-ylbenzamides have been designed,synthesized,and evaluated for their in vitro antimicrobial activities. among the tested compounds,3i was active against e. faecalis. © 2013 domenico armenise et al.