2-chloroquinoline-3-carbaldehyde ii: Synthesis,reactions,and applications

This review deals with synthesis and reactions of 2-chloroquinoline-3- carbaldehyde during the period from 1979 to 1999. the reactions are subdivided in groups that cover the reactions of chloro- and aldehyde substituent as well as reactions which involve both groups. some of these reactions have been applied successfully to synthesis of biologically important compounds. the main purpose of this review is to present a survey of the literature on 2-chloroquinoline-3-carbaldehyde chemistry and provide useful and up-to-date data for organic and medicinal chemist since such compound has not been previously reviewed in this period. © 2013 bakr f. abdel-wahab and rizk e. khidre.