Synthesis and bioevaluation of novel imatinib base derivatives via 1,1′-carbonyldiimidazole catalyst

A series of eleven compounds were synthesized from 6-methyl-n′-(4- (pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine with various substituted carboxylic acid under solvent-free conditions using 1,1′- carbonyldiimidazole (cdi) as a catalyst. the yields of compounds are more than 72%. all the compounds were characterized by physical,spectroscopic,and elemental analysis. compound 8b exhibited good inhibition towards antimicrobial activity compared to the other compounds. © 2013 m. j. patoliya and g. j. kharadi.