Imidazole: Having versatile biological activities

Imidazoles have occupied a unique position in heterocyclic chemistry,and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. thus,imidazole compounds have been an interesting source for researchers for more than a century. the imidazole ring is a constituent of several important natural products,including purine,histamine,histidine,and nucleic acid. being a polar and ionisable aromatic compound,it improves pharmacokinetic characteristics of lead molecules and thus is used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. there are several methods used for the synthesis of imidazole-containing compounds,and also their various structure reactions offer enormous scope in the field of medicinal chemistry. the imidazole derivatives possess extensive spectrum of biological activities such as antibacterial,anticancer,antitubercular,antifungal,analgesic,and anti-hiv activities. this paper aims to review the biological activities of imidazole during the past years. © 2013 amita verma et al.