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Synthetic studies on potent marine drugs: Synthesis and the crystal structure of 6- tert -butyl-4-phenyl-4 h -chromene-2-carboxylic acid
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نویسنده
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li h.-j. ,wang j.-l. ,wang r. ,luo d.-h. ,wu y.-c.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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4h-chromene-2-carboxylic acid ester derivatives of renieramycin m might be of use for the structural-activity relationship studies of antitumor antibiotic tetrahydroisoquinoline natural products. accordingly,6-tert-butyl-4-phenyl-4h- chromene-2-carboxylic acid,one key intermediate,was synthesized via the condensation of (3e)-2-oxo-4-phenylbut-3-enoate methyl ester with 4-tert-butylphenol in the presence of aucl3agotf (5 mol%),followed by cyclodehydration and aqueous hydrolysis. the product was unambiguously shown to the 4h-chromene-2-carboxylic acid by spectroscopy and x-ray crystallographic analysis. a packing diagram of the crystal structure shows that aromatic π-stacking interactions and o-ho hydrogen bond stabilize the structure in the solid. © 2013 hui-jing li et al.
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آدرس
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school of marine science and technology,harbin institute of technology, China, school of marine science and technology,harbin institute of technology, China, school of marine science and technology,harbin institute of technology, China, school of marine science and technology,harbin institute of technology, China, school of marine science and technology,harbin institute of technology,weihai 264209,china,stake key laboratory of natural and biomimetic drugs,peking university, China
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Authors
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