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An efficient and mild method for the synthesis and hydrazinolysis of N -glyoxylamino acid esters
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نویسنده
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el-faham a. ,al marhoon z. ,abdel-megeed a. ,siddiqui m.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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N-glyoxylamino acid ester derivatives were synthesized via the ring opening of n-acetylisatin using moderate conditions. during the hydrazinolysis of n-glyoxylamino acid ester derivatives with hydrazine hydrate (80%) in methanol,unexpected reduction of the α-keto group occurred to afford n-acylamino acid hydrazide derivatives in good yield (80-90%) (wolff-kishner type reaction). all the synthesized compounds were characterized by 1h nmr,13c nmr,and elemental microanalysis. © 2013 ayman el-faham et al.
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آدرس
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department of chemistry,college of science,king saud university,p.o. box 2455,riyadh 11451,saudi arabia,chemistry department,faculty of science,alexandria university,p.o. box 426,ibrahimia, Egypt, department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia, department of botany and microbiology,college of science,king saud university,p.o. box 2455,riyadh 11451,saudi arabia,department of plant protection,faculty of agriculture,alexandria university,saba basha, Egypt, department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia
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Authors
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