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A facile synthesis of pyrido[ 2 ′,3 ′:3,4]pyrazolo[1,5- a ]pyrimidine and Pyrido[2′,3 ′:3,4]pyrazolo[5,1-c ][1,2,4]triazine Bearing a Thiophene Moiety
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نویسنده
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elsaman t. ,fares m. ,abdel-aziz h.a. ,attia m.i. ,ghabbour h.a. ,dawood k.m.
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منبع
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journal of chemistry - 2013 - دوره : 2013 - شماره : 0
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چکیده
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Pyridinone derivative 8 was synthesized and transformed into the respective chloropyridine 9,which was allowed to react with hydrazine hydrate to afford pyrazolo[3,4-b]pyridin-3-amine derivative 11. compound 11 was used as a key intermediate for a facile synthesis of the title compounds 14,15,17,21a,b,and 24a-c where the reaction of 11 with some 1,3-dielecrophiles resulted in the formation of pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines 14,15,and 17,whereas diazotization of compound 11 gave the respective diazonium salt 18 which was coupled with some active methylene-containing compounds to give the corresponding hydrazones 19a,b and 22a-c. cyclization of the latter hydrazones yielded the pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazines 21a,b and 24a-c,respectively. © 2013 tilal elsaman et al.
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آدرس
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department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457, Saudi Arabia, department of pharmaceutical chemistry,college of pharmacy,egyptian russian university,badr city, Egypt, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457,riyadh 11451,saudi arabia,department of applied organic chemistry,national research center,dokki, Egypt, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457,riyadh 11451,saudi arabia,pharmaceutical and drug industries research division,department of medicinal and pharmaceutical chemistry,national research centre,dokki, Egypt, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457, Saudi Arabia, department of chemistry,faculty of science,cairo university, Egypt
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Authors
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