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New bioactive oleanane type compounds from Coriandrum sativum Linn.
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نویسنده
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iqbal m. ,bilal m. ,iqbal r. ,akram m. ,bakhsh baloch i. ,baloch m.k.
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منبع
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journal of chemistry - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Five (1-5) new bioactive oleanane type triterpenoids have been isolated from ethyl acetate soluble fraction of ethanolic extract of coriandrum sativum linn. of umbelliferae family. ethanolic extract of the whole plant was fractionated in organic solvents. ethyl acetate fraction was subjected to column chromatography on hplc rp-18 to get 1-oxo-11β,21β-dihydroxy-oleanane (1),1-oxo-11β-hydroxy-21β-o-acetyloleanane (2),1-oxo-11β-hydroxy-21β-o-angeloyloleanane (3),1-oxo-11β-o-angeloyl-21β-o-acetyloleanane (4),and 1-oxo-11β,21β-o-dibenzoyloleanane (5). the structures were elucidated after analysis of spectroscopic data,uv,ir,nmr (1h,13c,1d,and 2d),and mass measurements. suspension in water of crude ethyl acetate extract was employed to treat sheep with ringworm disease. all isolated compounds (1-5) displayed excellent activity in terms of inhibition zones,mics,mbcs,and mfcs against both bacteria and fungi. ethyl acetate extract showed excellent antiringworm activity in sheep. © 2014 muhammad iqbal et al.
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آدرس
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department of chemistry,gomal university, Pakistan, gomal college of veterinary sciences,gomal university, Pakistan, department of chemistry,gomal university, Pakistan, medicinal botanic centre,pcsir laboratories complex peshawar, Pakistan, department of chemistry,gomal university, Pakistan, department of chemistry,gomal university, Pakistan
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Authors
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