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Synthesis,characterization,x-ray crystal structure,and antimicrobial activity of 1,1′-(3,4-diphenylthieno[2,3-b ]thiophene-2,5-diyl)diethanone
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نویسنده
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mabkhot y.n. ,aldawsari f.d. ,al-showiman s.s. ,barakat a. ,choudhary m.i. ,yousuf s.
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منبع
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journal of chemistry - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Synthesis of 1,1′-(3,4-diphenylthieno[2,3-b]thiophene-2,5-diyl) diethanone (4) is reported here. the structure of compound 4 was deduced by 1h-nmr,13c-nmr,ft-ir,ms,microanalysis,and single-crystal x-ray diffraction. compound crystallizes in the monoclinic space group p21/n with a = 9.3126(7) å,b = 9.5867(7) å,c = 20.2811(15) å,α = 90°,β = 95.436(2)°,γ = 90°,v = 1802.5(2) å3,and z = 4. the molecules are packed in crystal structure by weak intermolecular c10-h10a⋯ s1 hydrogen bonding interactions. compound 4 can be a useful intermediate for the synthesis of diphenylthieno[2,3-b]thiophene. compound 4 was found to be active against gram-positive bacteria (bacillus subtilis and staphylococcus pneumoniae) and gram-negative bacteria (escherichia coli) and also was found to be active against fungi (aspergillus fumigatus and candida albicans). © 2014 yahia nasser mabkhot et al.
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آدرس
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department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh 11451,saudi arabia,king abdulaziz city for science and technology,p.o. box 6086, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh 11451,saudi arabia,department of chemistry,faculty of science,alexandria university,p.o. box 426,ibrahimia, Egypt, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh 11451,saudi arabia,h.e.j. research institute of chemistry,international center for chemical sciences,university of karachi, Pakistan, h.e.j. research institute of chemistry,international center for chemical sciences,university of karachi, Pakistan
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Authors
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