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Synthesis,single crystal x-ray structure,and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-[2-(morpholin-4-yl)ethyl] sulfanylpyrimidin-4(3 h)-one
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نویسنده
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attia m.i. ,el-brollosy n.r. ,kansoh a.l. ,ghabbour h.a. ,al-wabli r.i. ,fun h.-k.
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منبع
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journal of chemistry - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Synthesis,x-ray structure and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-[2-(morpholin-4-yl)ethyl] sulfanylpyrimidin-4(3h)-one (8) are reported. compound 8 exhibited activity towards s. aureus with mic value of 0.0619 mol/ml while it showed activity towards b. subtilis,b. cereus,c. albicans,and a. niger with mic = 0.1859 mol/ml. single crystal x-ray structure of the title compound 8 confirmed its s-alkylation. the title compound crystallizes in the triclinic,p -1,a = 11.1220 (5) å,b = 12.2241 (5) å,c = 21.5246 (9) å,= 88.958 (2)°,β = 79.836 (2)°,γ = 79.384 (2)°,v = 2830.9 (2) å3,z = 6,r (f) = 0.046,w r (f 2) = 0.110,t = 100 k. the crystal structure is stabilized by weak intermolecular c-h o and n-h o hydrogen interactions. © 2014 mohamed i. attia et al.
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آدرس
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department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457,riyadh 11451,saudi arabia,pharmaceutical and drug industries research division,medicinal and pharmaceutical chemistry department,national research centre,dokki, Egypt, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457,riyadh 11451,saudi arabia,department of chemistry,faculty of science,tanta university, Egypt, genetic engineering and biotechnology division,microbial chemistry department,national research centre,dokki, Egypt, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457, Saudi Arabia, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457, Saudi Arabia, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457, Saudi Arabia
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Authors
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