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Synthesis and in Vitro and in Vivo Evaluation of a New 68Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging
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نویسنده
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al-hokbany n.s. ,alotaibi b. ,bin amer s. ,okarvi s.m. ,al-jammaz i.
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منبع
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journal of chemistry - 2014 - دوره : 2014 - شماره : 0
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چکیده
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In an attempt to develop new tumor imaging radiotracers with favorable biochemical properties,we have synthesized new 68ga-2-acetylpyridine semicarbazone (68ga-[apsc] as a potential positron emission tomography (pet) tumor imaging agent using a straightforward and a one-step simple reaction. radiochemical yield and purity were quantitative without hplc purification. biodistribution studies in nude mice model bearing human mda-mb-231 cell line xenografts displayed significant tumor uptake of 68ga-[apsc]radiotracer after 2 h postinjection (p.i.). the initial results demonstrate that 68ga-[apsc]radiotracer may be useful probe for detecting and staging of hypoxic tumor using pet imaging modality. © 2014 n. s. al-hokbany et al.
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آدرس
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chemistry department,school of science,king saud university, Saudi Arabia, cyclotron and radiopharmaceuticals department,king faisal specialist hospital and research centre,p.o. box 3354, Saudi Arabia, cyclotron and radiopharmaceuticals department,king faisal specialist hospital and research centre,p.o. box 3354, Saudi Arabia, cyclotron and radiopharmaceuticals department,king faisal specialist hospital and research centre,p.o. box 3354, Saudi Arabia, cyclotron and radiopharmaceuticals department,king faisal specialist hospital and research centre,p.o. box 3354, Saudi Arabia
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Authors
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