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Design and synthesis of two oxazine derivatives using several strategies
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نویسنده
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lauro f.-v. ,francisco d.-c. ,marcela r.-n. ,elodia g.-c. ,eduardo p.-g. ,maría l.-r. ,lenin h.-h. ,betty s.-a.
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منبع
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journal of chemistry - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Several oxazine derivatives have been synthesized; nevertheless,expensive reagents and special conditions are required. therefore,in this study,two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2,3- dimethoxy-9,10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1h- naphtho[1,2-e][1,3-oxazin-2-yl)-2-phenyl-2,3-dihydro-1h-pyrazol-3-yl]-amino} -cyclobutanone and 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1,7,7-trimethyl- bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1h-naphtho[1,2-e][1,3] oxazin-2-yl)-2-phenyl-2,3-dihydro-1h-pyrazol-3-yl]-amino}-cyclobutanone) were synthesized using several strategies. the structure of compounds obtained was confirmed by elemental analysis,spectroscopy,and spectrometry data. in conclusion,the methods used offer some advantages such as good yields,simple procedure,low cost,and ease of workup. © 2014 figueroa-valverde lauro et al.
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آدرس
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laboratory of pharmaco-chemistry,faculty of chemical biological sciences,university autonomous of campeche,avenida agustín melgar s/n,col buenavista, Mexico, escuela nacional de ciencias biológicas,instituto politécnico nacional,prol,carpio y plan de ayala s/n,col santo tomas,11340 mexico, Mexico, facultad de nutrición,universidad veracruzana,médicos y odontólogos s/n,91010 xalapa, Mexico, laboratory of pharmaco-chemistry,faculty of chemical biological sciences,university autonomous of campeche,avenida agustín melgar s/n,col buenavista, Mexico, laboratory of pharmaco-chemistry,faculty of chemical biological sciences,university autonomous of campeche,avenida agustín melgar s/n,col buenavista, Mexico, laboratory of pharmaco-chemistry,faculty of chemical biological sciences,university autonomous of campeche,avenida agustín melgar s/n,col buenavista, Mexico, laboratory of pharmaco-chemistry,faculty of chemical biological sciences,university autonomous of campeche,avenida agustín melgar s/n,col buenavista, Mexico, faculty of medicine,university autonomous of campeche,avenida patricio trueba de regil s/n,col lindavista, Mexico
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Authors
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