Cardioprotective activity of N'',N''' -bis[5-methyl-2-oxo-1,2-dihydro-3h- indol-3-ylidene]carbonohydrazide derivative against doxorubicin induced cardiotoxicity in rats

The present study was aimed at evaluating the cardioprotective effect of novel synthetic n'',n''' -bis[5-methyl-2-oxo-1,2-dihydro-3h-indol-3-ylidene] carbonohydrazide derivative,by estimating the various biomarkers like creatine kinase-myoglobin (ck-mb),lactate dehydrogenase (ldh),aspartate aminotransferase (ast),and triglycerides (tg) in plasma and antioxidants like catalase,superoxide dismutase in heart tissue homogenate,and histopathological examination of heart tissues. the results showed the significant (p < 0.05) dose dependent decrease in elevated cardiotoxic biomarkers ck-mb,ldh,ast,and tg levels. the histopathological studies of heart tissues showed mild degeneration of muscle bundles and less interstitial edematous changes. the results showed the significant (p < 0.05) dose dependent increase in antioxidant enzymes catalase and superoxide dismutase in heart tissue homogenates. these observations enable us to conclude that n'',n''' -bis[5-methyl-2-oxo-1,2-dihydro-3h-indol-3-ylidene]carbonohydrazide has cardioprotective activity against doxorubicin induced cardiotoxicity. © 2014 salma tabassum et al.