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Synthesis and antibacterial activity of new spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] derivatives
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نویسنده
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el fal m. ,ramli y. ,zerzouf a. ,talbaoui a. ,bakri y. ,essassi e.m.
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منبع
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journal of chemistry - 2015 - دوره : 2015 - شماره : 0
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چکیده
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New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. these compounds were characterized on the basis of spectral and spectroscopic data (1h nmr,13c,ir,and ms). the antibacterial activity of the synthesized products was studied using bacterial strains: staphylococcus aureus,enterococcus faecalis,escherichia coli,and pseudomonas aeruginosa. compounds having an ethyl group showed the best activity with mic value of 31.25 μg/ml against staphylococcus aureus and streptococcus fasciens. © 2015 mohammed el fal et al.
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آدرس
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laboratoire de chimie organique hétérocyclique urac 21,faculté des sciences,université mohammed v, Morocco, medicinal chemistry laboratory,faculty of medicine and pharmacy,mohammed v university, Morocco, laboratoire de physico-chimie des matériaux inorganiques et organiques (lpcmio),ens, Morocco, laboratoire de biochimie et immunologie,faculté des sciences,université mohammed v, Morocco, laboratoire de biochimie et immunologie,faculté des sciences,université mohammed v, Morocco, laboratoire de chimie organique hétérocyclique urac 21,faculté des sciences,université mohammed v, Morocco
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Authors
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