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Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation
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نویسنده
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hwang j.t. ,kim s. ,yoon b.-r. ,choi i. ,choi s.y.
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منبع
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journal of chemistry - 2015 - دوره : 2015 - شماره : 0
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چکیده
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The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3t3-l1 cells by 96.8% at 50 m without cytotoxicity. in addition,4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner,as well as suppressing ppar-gamma activity,which controls fatty acid storage and glucose metabolism. based on these results,4-(4-methylbenzamino)benzoate shows potential as an antiobesity material. © 2015 jin taek hwang et al.
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آدرس
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korea food research institute,seongnam,south korea,korea university of science and technology, South Korea, college of pharmacy,seoul national university, South Korea, korea food research institute, South Korea, korea food research institute, South Korea, korea food research institute,seongnam,south korea,korea university of science and technology, South Korea
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Authors
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