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Microwave synthesis,characterization,and antimicrobial activity of some novel isatin derivatives
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نویسنده
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el-faham a. ,hozzein w.n. ,wadaan m.a.m. ,khattab s.n. ,ghabbour h.a. ,fun h.-k. ,siddiqui m.r.
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منبع
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journal of chemistry - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Three series of isatin derivatives [3-hydrazino,3-thiosemicarbazino,and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation. the prepared compounds were characterized by ft-ir,nmr,elemental analysis,and x-ray crystallography for derivatives 5b. the synthesized compounds were screened for antimicrobial activity against selected bacteria and fungi. the results revealed that the n-alkyl isatin derivatives were biologically active with different spectrums activity. most of the 3-hydrazino and 3-thiosemicarbazino isatin derivatives were biologically inactive and generally the active derivatives showed weak to moderate activity mainly against gram-positive bacteria. the imino isatin carboxylic acid derivatives (2-[4-(1-benzyl-5-bromo-2-oxoindolin-3-ylideneamino) phenyl]acetic acid,5d) showed promising activity against all tested gram-positive bacteria and against fungal pathogens. © 2015 ayman el-faham et al.
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آدرس
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department of chemistry,college of science,king saud university,p.o. box 2455,riyadh,saudi arabia,department of chemistry,faculty of science,alexandria university,p.o. box 426,ibrahimia, Egypt, zoology department,college of science,king saud university, Saudi Arabia, zoology department,college of science,king saud university, Saudi Arabia, department of chemistry,faculty of science,alexandria university,p.o. box 426,ibrahimia, Egypt, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457, Saudi Arabia, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457,riyadh,saudi arabia,x-ray crystallography unit,school of physics,universiti sains malaysia (usm), Malaysia, department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia
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Authors
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