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Synthesis of PAMAM dendrimers loaded with mycophenolic acid to be studied as new potential immunosuppressants
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نویسنده
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guazzelli l. ,d'andrea f. ,giorgelli f. ,catelani g. ,panattoni a. ,luvisi a.
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منبع
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journal of chemistry - 2015 - دوره : 2015 - شماره : 0
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چکیده
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The terminal n-boc protected diamino pamam 7 was condensed (edc-dmap) with two units of mycophenolic acid (mpa) giving the n-boc protected dendron 8 in a good yield (76%). the ammonium trifluoroacetate 9 was prepared from 8 by acid treatment (tfa-thf-h) and was split into two equal parts. the first half was treated with di-2-pyridyl thionocarbonate (dpt) in the presence of et to give the corresponding isothiocyanate 10. this was reacted with the second half of 9 providing the symmetrical dendrimer 11 (68% yield),exposing four mpa units around the thioureido-pamam core. © 2015 lorenzo guazzelli et al.
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آدرس
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department of pharmacy,university of pisa,via bonanno 33,pisa,italy,school of chemistry and chemical biology,university college dublin,belfield, Ireland, department of pharmacy,university of pisa,via bonanno 33, Italy, department of pharmacy,university of pisa,via bonanno 33, Italy, department of pharmacy,university of pisa,via bonanno 33, Italy, department of agriculture,food and environment,university of pisa,via del borghetto 80, Italy, department of agriculture,food and environment,university of pisa,via del borghetto 80, Italy
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Authors
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