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Studies on the protective effects of scutellarein against neuronal injury by ischemia through the analysis of endogenous amino acids and Ca2+ concentration together with Ca2+-ATPase activity
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نویسنده
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tang h. ,dong z.-x. ,gu t. ,li n.-g. ,tang y.-p. ,shi q.-p. ,guo j.-m. ,zhang p.-x. ,duan j.-a.
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منبع
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journal of chemistry - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Scutellarin,which is extracted from the dried plant of erigeron breviscapus,has been reported to protect the neural injury against excitotoxicity induced by ischemia. however,there are a few studies on the protective effects of scutellarein,which is the main metabolite of scutellarin in vivo. thus,this study investigated the neuroprotective effects of scutellarein on cerebral ischemia/reperfusion in rats by bilateral common carotid artery occlusion (bccao) model,through the analysis of endogenous amino acids using hilic-ms/ms,and evaluation of ca2+ concentration together with ca2+-atpase activity. the results showed that scutellarein having good protective effects on cerebral ischemia/reperfusion might by decreasing the excitatory amino acids,increasing the inhibitory amino acids,lowing intracellular ca2+ level,and improving ca2+-atpase activity,which suggested that scutellarein might be a promising potent agent for the therapy of ischemic cerebrovascular disease. © 2015 hao tang et al.
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آدرس
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jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China, jiangsu collaborative innovation center of chinese medicine resources industrialization,jiangsu key laboratory for high technology research of tcm formulae,nanjing university of chinese medicine, China
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Authors
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