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Synthesis and Characterization of Novel Thieno-Fused Bicyclic Compounds through New Enaminone Containing Thieno[2,3- b ]pyridine Scaffold
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نویسنده
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mabkhot y.n. ,aladdi s.s. ,al-showiman s.s. ,al-majid a.m.a. ,barakat a. ,ghabbour h.a. ,shaaban m.r.
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منبع
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journal of chemistry - 2015 - دوره : 2015 - شماره : 0
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چکیده
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New substituted thieno-fused bicyclic compounds named (1h-pyrazol-3-yl)thieno[2,3-b]pyridin-4(7h)-one derivatives (4a,b),2-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-3-methyl-7-phenylthieno[2,3-b]pyridin-4(7h)-one (5),phenylthieno[2,3-b]pyridin-4(7h)-one derivatives (6a-c,7a-c,and 8),and 3-(3-methyl-4-oxo-7-phenyl-4,7-dihydrothieno[2,3-b]pyridin-2-yl)-3-oxopropyl 4-chlorobenzoate (9) were synthesized by reacting the new enaminone (3) with different reagents. the chemical structure of the new molecules was determined by means of different spectroscopic methods such as nmr,ir,ms spectrometry,and by chn analyses. the molecular structure of the 1,1′-(3-methyl-5-(phenylamino)thiophene-2,4-diyl)diethanone (2) was successfully solved by x-ray single crystal. © 2015 yahia nasser mabkhot et al.
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آدرس
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department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh,saudi arabia,department of chemistry,faculty of science,alexandria university,p.o. box 426,ibrahimia, Egypt, department of pharmaceutical chemistry,college of pharmacy,king saud university,p.o. box 2457,riyadh,saudi arabia,department of medicinal chemistry,faculty of pharmacy,mansoura university, Egypt, department of chemistry,faculty of science,cairo university,giza,egypt,department of chemistry,faculty of applied science,umm al-qura university, Saudi Arabia
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Authors
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