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   Xanthine oxidase: Isolation,assays of activity,and inhibition  
   
نویسنده kostić d.a. ,dimitrijević d.s. ,stojanović g.s. ,palić i.r. ,dordević a.s. ,ickovski j.d.
منبع journal of chemistry - 2015 - دوره : 2015 - شماره : 0
چکیده    Xanthine oxidase (xo) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. excessive production and/or inadequate excretion of uric acid results in hyperuricemia. this paper presents a detailed review of methods of isolation,determination of xanthine oxidase activity,and the effect of plant extracts and their constituents on it. determining the content and activities of xo can be used for diagnostic purposes. testing inhibition of xo is important for detection of potentially effective compounds or extracts that can be used to treat diseases that are caused by increased activity of xo. in vitro bioassays are used to examine test material for xo inhibition,as inhibitors of xo may be potentially useful for the treatment of gout or other xo induced diseases. several authors reported on the xo inhibitory potential of traditionally used medicinal plants. © 2015 danijela a. kostić et al.
آدرس department of chemistry,faculty of science and mathematics,university of nis,visegradska 33, Serbia, department of chemistry,faculty of science and mathematics,university of nis,visegradska 33, Serbia, department of chemistry,faculty of science and mathematics,university of nis,visegradska 33, Serbia, department of chemistry,faculty of science and mathematics,university of nis,visegradska 33, Serbia, department of chemistry,faculty of science and mathematics,university of nis,visegradska 33, Serbia, department of chemistry,faculty of science and mathematics,university of nis,visegradska 33, Serbia
 
     
   
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