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Spectroscopic,Electrochemical,and in Silico Characterization of Complex Formed between 2-Ferrocenylbenzoic Acid and DNA
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نویسنده
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altaf a.a. ,lal b. ,khan n. ,badshah a. ,ullah s. ,akbar k.
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منبع
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journal of chemistry - 2016 - دوره : 2016 - شماره : 0
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چکیده
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We present the synthesis of 2-ferrocenylbenzoic acid (fcoh) and its electrochemical and spectroscopic characterization. fcoh was characterized for interaction with dna using theoretical and experimental methods. uv-visible spectroscopy and cyclic voltammeter (cv) were used for the experimental account of fcoh-dna complex. the experimental results showed that the fcoh interacts by electrostatic mode. the binding constant (k b) and gibbs free energy (δ g) for the fcoh-dna complex have been estimated as 5.3 � 104 m-1 and -6.44 kcal/mol,respectively. the theoretical dna binding of fcoh was studied with autodock molecular docking software. the docking studies yield good approximation with experimental data and explain the sites of binding. � 2016 ataf ali altaf et al.
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آدرس
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department of chemistry,university of gujrat,hafiz hayat campus,jalalpur jattan road,gujrat, Pakistan, department of energy system engineering,sukkur institute of business administration,sukkur, Pakistan, department of chemistry,quaid-i-azam university,islamabad, Pakistan, department of chemistry,quaid-i-azam university,islamabad, Pakistan, department of chemistry,quaid-i-azam university,islamabad, Pakistan, graphene research institute,sejong university,seoul, South Korea
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Authors
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