Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives

Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. a series of eleven new compounds of n′-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide derivatives were obtained via reaction of 2-[4-(4-nitrophenyl)piperazin-1-yl]acetohydrazide with aromatic aldehydes. the chemical structures of the compounds were enlightened by ft-ir,1h-nmr,13c-nmr,and hrms (esi) spectral data. the inhibition potency of the compounds 3a-k against ache and buche was measured and evaluated using a modification of ellman's spectrophotometric method. among the tested compounds,compound 3c was assigned to be the most active derivative. galantamine was used as a standard drug. � 2016 bet�l kaya et al.