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Novel palladium(II) and platinum(II) complexes with a fluoropiperazinyl based ligand exhibiting high cytotoxicity and anticancer activity in vitro
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نویسنده
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abu-safieh k.a. ,abu-surrah a.s. ,tabba h.d. ,almasri h.a. ,bawadi r.m. ,boudjelal f.m. ,tahtamouni l.h.
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منبع
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journal of chemistry - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Cis-dichloro-palladium(ii) and cis-dichloro-platinum(ii) complexes (2,4) of the general formula [m(n-n)cl2] (m=pd(ii) and pt(ii),n-n= 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl) benzene,(dfmpb)) and the dicationic palladium(ii) complex [pd(n-n)(ch3cn)2](bf4)2 (3) have been prepared and characterized by elemental analysis,1h-nmr-,mass spectroscopy,and ir spectroscopy. the cytotoxic effect of these complexes against mda-231 and mcf-7 human breast cancer cell lines and k562 human leukemia cell line has been studied. the influence was dose dependent and varies with cell type. the palladium(ii) complex (2) showed superior cytotoxic effect compared with the corresponding platinum(ii) complex and the standard,cisplatin,when tested against all the above cell lines. © 2016 kayed a. abu-safieh et al.
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آدرس
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department of chemistry,hashemite university,p.o. box 150459,zarqa, Jordan, department of chemistry and earth sciences,college of arts and sciences,qatar university,p.o. box 2713,doha, Qatar, department of chemistry and earth sciences,college of arts and sciences,qatar university,p.o. box 2713,doha, Qatar, department of chemistry,hashemite university,p.o. box 150459,zarqa, Jordan, department of physiology and biochemistry,university of jordan,amman, Jordan, department of physiology and biochemistry,university of jordan,amman, Jordan, department of biology and biotechnology,hashemite university,zarqa, Jordan
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Authors
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