Synthesis and Antibacterial Activity of Some Derivatives of 2-Methylbenzimidazole Containing 1,3,4-Oxadiazole or 1,2,4-Triazole Heterocycle

5-[(2-methyl-1h-benzimidazol-1-yl)methyl]-1,3,4-oxadiazole-2-thiol or 5-[(2-methyl-1h-benzimidazol-1-yl)methyl]-4-(4-methylphenyl)-1,2,4-triazol-3-thiol which were prepared starting from 2-methylbenzimidazole in the reaction with appropriate n-aryl-2-chloroacetamides afforded two series of n-aryl-2-{5-[(2-methyl-1h-benzimidazol-1-yl)methyl]-1,3,4-oxadiazol-2-yl}sulfanylacetamides and n-aryl-2-{5-[(2-methyl-1h-benzimidazol-1-yl)methyl]-4-(4-methylphenyl)-4h-1,2,4-triazol-3-ylthio}acetamides,respectively. the structures of the compounds were elucidated on the basis of ir,ms,1h-nmr,and 13c-nmr spectral data. the compounds containing 1,3,4-oxadiazole or 1,2,4-triazole heterocycle also were tested for their antimicrobial activity against bacteria,mold,and yeast. © 2016 cong nguyen tien et al.